I used to use ISAPI_Rewrite to rewrite HTML static URLs with dynamic links in Window 2000 IIS5.0.
After recently upgrading to Widnows 2003 IIS6.0, I found that ISAPI_Rewrite could not run at all. In IIS 6.0, it kept prompting "Not Loading". I checked later. After checking again, it turned out to be a file permissions issue.
IIS 6.0 ISAPI_Rewrite runs under the Service account. After giving the read and write permissions to the data file to the Service account, ISAPI_Rewrite can finally run normally.