Adobe seems to have put a lot of effort into the CS4 suite. Last month Adobe released CS4 trial versions of Dreamweaver, Fireworks and Soundbooth. The most obvious change in the CS4 suite is the user interface, and this change is also reflected in Photoshop CS4.
Judging from the screenshots, Photoshop CS4 has a tougher interface, with a new column display function and two newly added 3D editing keys in the toolbar.